-Amylase binding-interaction with JCAE was also investigated using fluorescence spectroscopy and molecular docking. However, scientifically it is called Justicia carnea. This suggested that the extract did not alter tissue function in converting harmful hydrogen peroxide to water and oxygen. It is not. While graded doses of J. carnea ethanol extract showed no significant difference in the liver and kidney GSH compared to the control, only rats that received 1200mg/kg body weight JCEE statistically decreased in the kidney. Walters DM., Cho Hye-Youn, Kleeberger SR. Oxidative Stress and Antioxidants in the Pathogenesis of Pulmonary Fibrosis: A Potential Role for Nrf2. Side effects of Ewe eje (Justicia carnea leaf Side Effects) Ewe eje is safe and healthy for consumption. Anal Biochem. Keep in mind that natural products are not always necessarily safe and dosages can be important. Medapa S, Singh GRJ, Ravikumar V. The phytochemical and antioxidant screening of Justicia wynaadensis. 1978;90:819. 2. White blood cell counts usually increases following foreign invaders (pathogens) resulting in normal body physiological response which boost the bodys defense mechanisms [28, 29]. The LD50 of extract was greater than 5000mg/kg body weight. Rats were further observed for extended hours of 48h to see if mortality would occur. 217-230. The possible anti-anaemic property of the leaf could be linked to the improved hemoglobin, PCV and RBC observed in this study. In these groups, from mild to severe order; shows observable congested portal vein, the liver parenchyma showed area of harmorrhage, the morphology of the hepatocytes appear pyknotic, some show mild fat infiltration (red arrow) the sinusoids appear fibrotic with infiltration of inflammatory red cells (red arrow). A total number of forty two (42) male albino rats weighing between 120 and 170g were used in this study. It is very rich in iron, a major component is RBC hemoglobin. The absorbance of the supernatant was measured against reagent blank at 532nm. Ewe eje can increase blood count and volume. 400). The plant looks great along garden borders and near building foundations. Studies have also confirmed this claim. B-vitamins are good sources of energy. Ewe eje is an age-old herb medically proven to act as a blood tonic which can be attributed to its nutritional composition. While vitamin A maintains good vision, vitamin B are good for cellular functions such as metabolisms and energy production, and improve brain functioning. When you boil the plant, it turns the water red. The absorbance was taken at interval of 1min for 3min at 480nm. Different drugs are used but many depend mainly on plants and herbal products for its treatment. Olaniyan JM, Hadiza LM, Hussaini AM, Musa BB, Abubakar SA. View abstract. J Ethnopharmacol. Materials and Methods Chariandy, C. M., Seaforth, C. E., Phelps, R. H., Pollard, G. V., and Khambay, B. P. Screening of medicinal plants from Trinidad and Tobago for antimicrobial and insecticidal properties. Ewe eje as a Natural Blood booster/tonic: Due to the high concentration of iron in this leaf, it can help boost blood production by increasing the red blood cells, haemoglobin, and the blood platelets. Diallo A, Gbeassor M, Vovor A, Eklu-Gadegbeku K, Aklikokou K, Agbonon A. Mr. K.O. de Smet, P. A. Plantcaretoday.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to amazon.com, how to get rid of leaf eating caterpillar. They can easily tolerate acidic to slightly alkaline sandy, loamy, and clay soils. Anthonia OC, Ikechukwu UR, Uzoma NO, Sunday ELU. CAS The animals were initially examined for any signs of toxicity after 60min of administration and further observed for a period of 24h. The absence of rat mortality in phase I necessitated the conduct of the second phase. The indistinguishable differences of total protein in the liver and kidney of rats treated with ethanol extract of J. carnea could indicate that the plant extract did not alter protein synthetic function of the organs. J Ethnopharmacol. Cover and leave for about fifteen minutes. By using this website, you agree to our Clinical Guide to Laboratory tests. No. ESA conceived and designed the study. J Ethnopharmacol. When there is high cholesterol level in your blood, LDL- and VLDL- cholesterols are being deposited on the arterial wall of blood vessels, thereby blocking free flow of blood and increasing blood pressure. Biomed Res. MacRae, W. D. and Towers, G. H. Justicia pectoralis: a study of the basis for its use as a hallucinogenic snuff ingredient. Compared to the control, total protein in liver and kidney were statistically not altered except rats that were administered with 1200mg/kg JCEE that showed significant (p<0.05) decrease in the liver. Ewe eje is mainly given to persons who want a blood boost such as pregnant women, persons suffering from anemia and other convalescents. Corra, GM., de C. Alcntara, AF. II. Cardioprotective role of Justicia traquebareinsis Linn. Check these Great Plant Combination Ideas with Justicia, Eye-Catching Retaining Walls and Staircases, An Eye-Catching Mediterranean Garden with Agave, Aloe and Pincushion, A Striking Water-Wise Border with Agave, Cactus and Ocotillo, A Beautiful Duo with Agave 'Blue Flame' and 'Blue Glow', A Long-Lasting Summer Garden Idea with Marigold and Sage, 8, 9, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, H1, H2. CAS Several medicinal plants such as Xylopia aethiopica [25], Tectona grandis [26] and extracts of M. indica, A. hybridus and T. occidentalis [27] have also been reported to elevate RBC, hemoglobin and packed cell volume. Based on estimation by World Health Organization (WHO), larger percentage (between 80 and 90%) of the worlds population especially in developing countries depends on traditional system of medicine [1, 2]. Ewe eje isn't capable of causing any side or negative effects if consumed moderately. volume7, Articlenumber:2 (2021) The compound responsible for this activity is lignan. Rats that received 50 and 100mg/kg body weight JCEE showed significant (p<0.05) increase in liver weight while other doses showed no significant difference compared to the control. 2004;19(12):16. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. However, lowest (50mg/kg) dose of extract significantly elevated MCH and MCHC. The Pros and Cons of Creatine You Should Know. Why urban citizens in developing countries use traditional medicines: the case of suriname. Part of Haematological and biochemical studies on Justicia carnea leave extract in phenylhydrazine induced-anemia in albino rats. The botanical name- Justicia carnea was coined after a scotish- James Justice, who happens to have found the plant first. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. You can add the leaves and water altogether in a pot and allow to boil till the water turns red. Brazilian-plumeflowers are best propagated from softwood cuttings. However, caution should be taken as higher dose at 1200mg/kg could cause noticeable tissue injury. et al. Kidney weight of rats treated with JCEE showed no significant difference with exception in 800mg/kg JCEE that demonstrated significant reduction. In recent time, copious attention has been focused on the use of medicinal plants in the management and treatment of ailments such as anemia, diabetes and malaria. As for light exposure, keep the plant away from the full sun. However, there have not been scientific backing on this claim, yet, from the antiviral properties of other species of justicia, it could be that this plant possess antiviral properties which is utilized in the treatment of hepatitis infection. These compounds beyond boosting your blood concentration, thereby enhancing the transport of nutrients to various parts of the body, also boost your immune system against several infectious diseases. J Ethnopharmacol 1984;12(1):93-111. Rich, well-drained soil retaining ample moisture is the perfect home for Brazilian plume flowers. Only plants will be removed from the collection. Ethanol extracts of J. carnea leaf increased RBC, hemoglobin and platelet with significant increase (p<0.05) in groups that received higher dose (>500mg/kg b.w) of extract compared to the control. Once the roots have established, adjust watering to three to five days apart. Badami S, Aneesh R, Sankar S, Sathishkumar MN, Suresh B, Rajan S. Antifertility activity of Derris brevipes variety coriacea. Karigidi is a lecturer in the Biochemistry unit of Chemical Sciences Department, Olusegun Agagu University of Science and Technology, Okitipupa, Ondo State, Nigeria. Ani, Onuabuchi & Udedi, Stanley & Asogwa, Kingsley & Enemali, Michael & Onwelumadu, Chigozie & Ikedife, Kenneth. The effects of ethanol extract of J. carnea leaf on total protein concentration and antioxidant system in liver and kidney of normal wistar rat is presented in Table 4. No observable focal sclerosis of renal glomeruli, capsular spaces around the glomerulus appears normal with distinct layering of renal microcellular structures. what are the pros and cons of testosterone replacement therapy? Ewe eje is a rich source of phytochemicals, minerals and vitamins. Meth Enzymol. Biomed Environ Mass Spectrom 1988;15(8):413-417. It also increases good cholesterol levels. Prepare the existing soil by breaking it up with a spade or hoe. Liver superoxide dismutase (SOD) activity was significantly (p<0.05) increased at 1200mg/kg while other tested doses caused no detrimental effect on glutathione, catalase, SOD and malondialdehyde level in liver and kidney. The Portal triad (blue arrow) composed of the hepatic vein and artery as well as the bile duct (PT), the well distributed hepatocytes (H) (yellow arrow) and hepatic sinusoids (black arrow) are demonstrated across study groups. Results obtained from the acute oral toxicity study revealed tolerance of experimental rat to acute administration of J. carnea ethanol extracts since no mortality and signs of toxicity were observed after 24h (Table1). While not necessary, prune the justicia (plant) freely to maintain the desired shape and size. This is due to the inability of the pancreatic beta cells to secrete insulin, which transports glucose to cells, or the inability of cells of the body to recognize insulin. Decoction of ewe eje or its leaf extract can lower serum cholesterol and get rid of bad cholesterol (LDL). The appropriate dose of Justicia pectoralis depends on several factors such as the user's age, health, and several other conditions. The effect of the ethanol extract of Justicea. The present study investigated the antioxidant and in vitro antidiabetic capacities of Justicia carnea aqueous leaf extract (JCAE) using -amylase inhibition model. The results of effect of methanol leaf extract of Justicia carnea on albumin and total protein concentrations in CCl 4-intoxicated rats shown as in Table 2 showed that there was a significant (p<0.05) decrease in serum albumin and total protein concentrations . The resultant liquid would turn crimson red. 3rd ed. In an acute exposure of experimental rats to single oral doses of extract, no mortality and signs of adverse effects were observed. Decreased white blood cell count was obtained in this report, the level of lymphocyte and granulocyte was not altered by the extract while MID sized cell was significantly elevated at 500 and 800mg/kg dose. Related: The Persian Shield plant is also in the Acanthaceae family. Justicia carnea is commonly cultivated and grown as an ornamental potted plant. 50mg/kg-1200mg/kg treatment relative to control treatment showed varied degree of renal injury that is dose dependent. In a study conducted by Onyeabor and colleagues, the leaf extract of jusiticia carnea reverses the anemic effect of phenylhydrazine on the pack cell volume, red blood cell, and hemoglobin concentrations. Provided by the Springer Nature SharedIt content-sharing initiative. The absorbance was read at 412nm against the reagent blank. These tropical plants are not very fussy about soil. Materials and Methods Plant material Justicia carnea leaves used in this study were collected from Ozalla Isuofia in Anambra State and identified by Mr. Ozioko Justicia carnea, the Brazilian plume flower, Brazilian-plume, flamingo flower, or jacobinia, is a flowering plant in the family Acanthaceae. The renal tubules and interstitial spaces appears distorted with presence of red inflammatory cells infiltrating the renal interstitial spaces as well as focal sclerosis of renal glomeruli with associated degeration of the glomerular membrane. The Justicia carnea leaves are rich in B-vitamins. They protect our cells from the harmful effects of reactive oxygen species. I do hope that after reading through this article, you would plan to start cultivating this amazing plant specie in your garden. He is a research assistant in the Biochemistry Unit of the same Department. It also grows in some Caribbean islands, including Trinidad and Tobago. A cup of water Akintimehin is a lecturer in the Biochemistry unit of Chemical Sciences Department, Olusegun Agagu University of Science and Technology, Okitipupa, Ondo State, Nigeria. Ewe eje improves the production of white blood cells and other antibodies, all which are essential for strengthening immunity. The authors acknowledge the Director and staff of Peak Health Diagnostic and Research Laboratory, Ibadan, Oyo State, Nigeria, for the technical support and interpretation of the histology. African J Plant Sci. Ethanol extract of J. carnea leaf elevated red blood cell, hemoglobin, packed cell volume and platelet count with significant increase at higher doses of extracts compared to the control. Clin Phytosci 7, 2 (2021). Daily intake of the Ewe eje or ajeri can increase the absorption of iron and vitamins, Uses and health benefits of Ewe eje (Justicia carnea leaf). Justicia carnea (belonging to Acanthaceae family) is a flowering plant consisting ~600 species that are widely distributed in the tropics and subtropics [7]. The plants cannot be propagated with seeds. Relative to control, lymphocyte and granulocyte exhibited no significant difference in all doses while MID was elevated in treated groups with significant increase in rats administered with 500 and 800mg/kg body weight. In its native habitat, the Justicia carnea plant grows upright and may reach 3 5 feet tall. In the winter, temperatures between 60 64 degrees Fahrenheit (15 18 C) are ideal. Anal Biochem. SOD is involved in the dismutation of the highly reactive superoxide anion to molecular oxygen (O2) and to less reactive hydrogen peroxides (H2O2) species, whereas CAT removes hydrogen peroxide (H2O2) and toxic hydroxyl radical into water molecule [35]. So lets go through this together. However, serious caution of the dose should be taken into consideration when extrapolating this result for human consumption. J Nat Prod 1988;51(4):804-805. 10.17306/J.AFS.2017.0492. 5. Safety assessment of oral administration of ethanol extract of Justicia carnea leaf in healthy wistar rats: hematology, antioxidative and histology studies. Tissues were processed automatically using automatic tissue processor (Leica TP 1020) and allowed to pass through varying percentage of alcohol and absolute alcohol for the purpose of dehydration following dewaxing in Xylene for 15mins. Therefore,it is imperative to investigate the effects of the plant on the essential biochemical indices in diabetic rats so as to establish its safety. Due to the local availability, easy access and relatively low cost, medicinal plants are gaining attentions in health care programmes. J Acute Disease. Previously, J. carnea leaf has been reported to contain high quantity of phytochemical constituents (such as saponins, alkaloids and terpenoids), vitamins (A, C and E) and minerals [9, 10]. Corroborating with the results of the antioxidant system and weight of the liver, continuous exposure to higher dose (1200mg/kg) of JCEE could result in hepatic damage. A multidisciplinary overview of intoxicating snuff rituals in the western hemisphere. This is . Ewe eje as it is fondly called by the Westerners in Nigeria is a plant known for its blood boosting abilities.