Biotechnol. J. Pharm. Artif. Specifically, the use of nanocarriers for drug delivery offers many advantages; (i) circumvent the problems of solubility and stability of anticancer drugs; (ii) prevents the drug from degradation from proteases and other enzymes and increase the half-life of the drug in the systemic circulation; (iii) improves drug distribution and targeting; (iv) helps in the sustained release of drug by targeting the cancer sites and (v) helps in delivery of multiple drugs and, therefore helps inreducing drug resistance [23]. Cells were incubated for 48h and BCL-2 siRNA concentration used is 20nM (c); Mean tumor volume determined using magnetic resonance imaging measured after 25days of the first injection. -, Quazi S (2021) Telomerase gene therapy: a remission towards cancer. 41(7), 29713010 (2012), D. Zhu et al., Docetaxel (DTX)-loaded polydopamine-modified TPGS-PLA nanoparticles as a targeted drug delivery system for the treatment of liver cancer. pp. 527(1), 142150 (2017), Y. Huang et al., Superparamagnetic iron oxide nanoparticles conjugated with folic acid for dual target-specific drug delivery and MRI in cancer theranostics. Biopharm. Cookies policy. 67(4), 1555 (2007), S.M. Cancer Res. IET Nanobiotechnol. Recently, nanotechnology and nanoparticles have attracted great interest in cancer therapeutics as they can provide improved and targeted drug delivery systems to overcome the drawbacks of conventional chemotherapy. National Library of Medicine Funct. The in vivo antitumor studies were conducted on male BALB/C nude mice bearing a HepG2 tumor model. Consequently, the use of well-planned and -designed manufacturing processes are essential, and the clinical benefit must be huge which can justify the manufacturing costs. B Biointerfaces 170, 514520 (2018), E. Heidarli, S. Dadashzadeh, A. Haeri, State of the art of stimuli-responsive liposomes for cancer therapy. Artif. Mater. However, the detection of cancer in the early stage has been hindered by the intrinsic limits of conventional cancer diagnostic methods. Biomed. A novel drug delivery system based on carbon nanospheres for delivery of cancer therapeutics has been evaluated for internalization, and possible mechanism of endocytosis and biodistribution in mice [206]. Soc. Pharm. Control. Nanotechnol. The large-scale production of nanoformulations, however, is quite challenging as their physicochemical properties may vary from batch to batch. Sci. Nanotechnology in cancer diagnosis: progress, challenges and opportunities In the fight against cancer, early detection is a key factor for successful treatment. 46, 2533 (2018), Z. Wei et al., Antitumor effect of a Pt-loaded nanocomposite based on graphene quantum dots combats hypoxia-induced chemoresistance of oral squamous cell carcinoma. Miranda et al., Array-based sensing of proteins using conjugated polymers. B 3(39), 77247733 (2015), J. Zhang et al., pH-sensitive polymeric nanoparticles for co-delivery of doxorubicin and curcumin to treat cancer via enhanced pro-apoptotic and anti-angiogenic activities. The in vitro studies discovered that the nanoparticledrug conjugate was more efficient in killing PMSA-expressing cells. Understanding the complications involved in cancer cell physiology and the tumor microenvironment, along with drug and carrier pharmacokinetics is essential for the development of successful new cancer therapeutics. This accumulation of the drug at the tumor sites is a passive process, and it requires prolonged circulation of the drug for appropriate drug delivery. The review is based on the published data and sources of data upon which conclusions have been drawn can be found in the reference list. Similar to Au nanoparticles,silver (Ag) nanoparticles havealso been demonstrated to be used as anticancer agents for the treatment of multiple types of cancer [144,145,146,147]. Natl. 2018;22:24. doi: 10.1186/s40824-018-0133-y. 15(6), 21942205 (2018), M.U. These liposomal formulations exhibited negative zeta potential values and an in vitro release study demonstrated that the liposomal formulations displayed good stability, and an extended circulation time required to avoid drug clearance before arrival at the target cells. To overcome the hypoxia-mediated chemoresistance of oral squamous cell carcinoma (OSCC), platinum loaded, polyethylene glycol-modified graphene quantum dots (GPt) have been utilized. Res. In redox-activated drug release mechanism, a redox-responsive nanocarrier containing functional groups that reacts upon contact with oxidizing and/or reducing environment in and around cancer cells (peroxides, GSH, and free radicals), undergoing to chemical bond cleavage [63]. Clipboard, Search History, and several other advanced features are temporarily unavailable. Soft Matter 14(12), 24002410 (2018), A. Siriviriyanun et al., Cyclodextrin- and dendrimer-conjugated graphene oxide as a nanocarrier for the delivery of selected chemotherapeutic and photosensitizing agents. All these observations are motivating and may change the face of cancer treatment and management. Sci. 11(8), 20712082 (2015), K. Hayashi et al., Magnetically responsive smart nanoparticles for cancer treatment with a combination of magnetic hyperthermia and remote-control drug release. Mater. Breast Dis. Also, these platforms can provide competent drug delivery systems responsive to various stimuli to enhance the therapeutic efficacy and reduce the side effects of loaded drugs. J. 2018 Feb 1;125:1-2. doi: 10.1016/j.addr.2018.04.014. Biol. Discusses the limitations of target therapy for some cancer patients. The surface charge of the nanoparticles is one of the leading factors to direct the interaction at the nano-bio interface [23]. Linear type of FC131 (LFC131) ligand conjugated, doxorubicin encapsulated polyamide amine dendrimer was developed using polyamide amine dendrimer generation 4.0 (D4). NanoBiotechnology 3(1), 4045 (2007), A. Verma, V.M. Brito C, Loureno C, Magalhes J, Reis S, Borges M. Vaccines (Basel). These nanoparticles exhibited a significant decrease in cell viability and greater cytotoxicity toward LNCaP cells when compared to free resveratrol. C 82, 291298 (2018), C. Chittasupho, S. Anuchapreeda, N. Sarisuta, CXCR284 targeted dendrimer for anti-cancer drug delivery and breast cancer cell migration inhibition. Release 172(3), 852861 (2013), S.K. Further, they measured the localization and internalization of these nanoparticles using magnetic resonance imaging (MRI) exploiting IONPs properties as contrast agents. 60(15), 16151626 (2008), A. Varki, Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins. Nanomaterial-based smart, targeted systems exploit the multivalent nature of interactions of ligands with the target antigens. All samples were stained with 0.5% uranyl acetate for 1min. Mesoporous silica nanomaterials (MSNs) have emerged as another class of drug delivery carriers, due to their surface properties such as large surface area, uniform porosity, stability, low toxicity and narrow size distribution [217]. 2023 Mar 15;14:1101320. doi: 10.3389/fphar.2023.1101320. Navya et al., Single step formation of biocompatible bimetallic alloy nanoparticles of gold and silver using isonicotinylhydrazide. Artif. Endoplasmic retention is only one of the mechanisms describing tumor biology. 8d, e was determined by magnetic resonance imaging and showed that temozolomide and siRNA conjugated nanocomplex had a volume of 8211mm3 which is much less than the volume resulting with the other treatments. Acta Biomater. Control. Due to variable endothelial gaps resulting from vigorous tumorous cell growth, it can result in non-uniform extravasation of nanoparticles into the target area [36]. Int. J. Pharm. In open-loop control systems, external factors such as magnetic pulses, thermal, acoustic pulses or electric fields control drug release. Nanotechnol. There was a 27% increase in the cellular uptake of cells treated with magnetic mesoporous silica nanomaterials with epirubicin in the presence of external magnetic field when compared to free epirubicin [226]. Colloids Surf. Liposomes can be conjugated with poly(ethylene glycol) (PEG), targeting ligands and/or antibodies, polysaccharides on the external surface to enhance solubility, to increase the hydrophilicity and to provide passive and active targeting functions, in due course attaining high drug efficiency with low toxicity [233]. 528(1), 485497 (2017), T. Lv et al., Role of generation on folic acid-modified poly(amidoamine) dendrimers for targeted delivery of baicalin to cancer cells. National Library of Medicine Effect of OVA-iron oxide nanoparticles: macrophages activation with different concentrations of OVA, and production of a TNF-, b IL-6, c IFN-. 516, 332341 (2018), M. Manzano, M. Vallet-Reg, Mesoporous silica nanoparticles in nanomedicine applications. Biopharm. Eng. Formulations have been approved for the treatment of Kaposis sarcoma, acute lymphoblastic leukemia, pancreatic cancer, ovarian cancer, multiple myeloma and metastatic breast cancer including Doxil, Myocet, DaunoXome, DepoCyte, Lipoplatin. Roopan, Biosynthesis and characterization of copper oxide nanoparticles and its anticancer activity on human colon cancer cell lines (HCT-116). The advent of nanotechnology has revolutionized the arena of cancer diagnosis and treatment. Progress in materials science and nanotechnology have brought nanomaterials-based formulations/drugs to the forefront of medical research, emerging as potential tools for cancer treatment and management. Oncol. A recent investigation reported that single walled carbon nanotubes were toxic, and induced death of the organs at higher dosages, whereas multi-walled carbon nanotubes in lower dosages could effectively deliver drug for targeted therapy of abnormal cells in breast cancer [205]. Trace Elem. Modulating rate of drug release in response to an activation signal constitutes an essential strategy to achieve controlled release purposes as well as maintaining effective therapeutic dosage over a stretch of time. Ind. 12, 14531464 (2017), X. Hua et al., Magnetically triggered drug release from nanoparticles and its applications in anti-tumor treatment. Cancer Facts & Figures 2021 | American Cancer Society. Nano-Bio Interfacial Research Laboratory (NBIRL), Department of Biotechnology, Siddaganga Institute of Technology, Tumkur, Karnataka, 572103, India, Melbourne Integrative Genomics, School of BioSciences/School of Mathematics and Statistics, The University of Melbourne, Melbourne, VIC, 3010, Australia, School of Optometry, Indiana University, Bloomington, Indiana, 47405, USA, Centre for Advanced Materials and Industrial Chemistry, School of Science, RMIT University, Melbourne, VIC, 3001, Australia, Suresh Kumar Bhargava&Hemant Kumar Daima, Department of Chemistry, University of Massachusetts (UMass) Amherst, 710 North Pleasant Street, Amherst, MA, 01003, USA, Amity Institute of Biotechnology, Amity University Rajasthan, Kant Kalwar, NH-11C, Jaipur-Delhi Highway, Jaipur, Rajasthan, 303002, India, Department of Biotechnology, Bannari Amman Institute of Technology, Sathyamangalam, Erode, Tamil Nadu, 638401, India, You can also search for this author in Biol. In spite of widespread research and the preclinical development of liposomal formulations from several decades, only a few liposomal drug formulations have been approved by the FDA for clinical use [246]. Several studies have demonstrated enhanced antitumor activity with targeting moieties. Tailor-made nanomaterials functionalized with specific ligands can target cancer cells in a predictable manner and deliver encapsulated payloads effectively. J. Pharm. Disadvantages Nanotechnology offers many potential advantages, however, there are also potential disadvantages of nanotechnology, including: Health risks: There is some concern that exposure to nanoparticles could be harmful to human health, as they can easily penetrate cells and tissues. Nat. Biomol. 2006 May;6(3):307-18. doi: 10.1586/14737159.6.3.307. Rev. These smart nanosystems trigger the release of the drug trapped in the pores to the target sites in the presence of either endogenous or exogenous stimuli, with control on the administered dose. By exploiting the extended circulation property of PEGylated liposomes and biocompatibility, biodegradability and hydrophilicity of polysialic acid, a negatively charged polysaccharides drug delivery systems developed that has been used to prolong the circulation time of the liposomes, increasing the ability of epirubicin to reach the tumor sites. Commun. Hematol Oncol Clin North Am. Nano Convergence 6, 23 (2019). 8600 Rockville Pike J. Nanomed. J. Nanomed. Multifunctional graphene smart nanomaterials have been developed for drug delivery and cellular imaging in cancer treatment [210, 213]. The effectiveness of anticancer drug treatment can be achieved only when the administered drug is of proper dosage and display maximal activity in the cancer cells. The regulatory verdicts on the nanoformulated drugs are based on the individual assessment of paybacks and perils, making evaluations a time-consuming affair that causes delays in commercialization. Acad. Mater. Sci. ACS Nano 4(1), 251258 (2010), H. Zhang et al., Daunorubicin-TiO2 nanocomposites as a smart pH-responsive drug delivery system. Mol. Healthc. Farooq et al., Gold nanoparticles-enabled efficient dual delivery of anticancer therapeutics to HeLa cells. -. Mater. In another study, resveratrol encapsulated PLGA [poly(lactic-co-glycolic acid)] nanoparticles have been constructed for prostate cancer therapy. Mock et al., Evidence for distinct mechanisms of uptake and antitumor activity of secretory phospholipase A2 responsive liposome in prostate cancer. Expert Rev Mol Diagn. 2010;10(1):428-55. doi: 10.3390/s100100428. 119, 310321 (2017), K. ztrk et al., Effective targeting of gemcitabine to pancreatic cancer through PEG-cored Flt-1 antibody-conjugated dendrimers. Elias et al., Effect of ligand density, receptor density, and nanoparticle size on cell targeting. Photobiol. 46(43), 1483114838 (2017), N. Li et al., Curcumin-loaded redox-responsive mesoporous silica nanoparticles for targeted breast cancer therapy. Unable to load your collection due to an error, Unable to load your delegates due to an error. There are several studies reporting on successful applications of passive targeting of tumor cells and a successful translation into clinical therapeutics. Biomaterials 30(5), 859866 (2009), Y.-I. Hobbs et al., Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. 27(11), 23432355 (2010), M.J. Ernsting et al., Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles. Nanoscale 6(2), 758765 (2014), H.K. B Biol. [48] synthesized insulin-like growth factor 1 (IGF1) and conjugated it to magnetic iron oxide nanoparticles (IONPs) having the anthracycline doxorubicin as therapeutic payload. The ensuing section discusses major physicochemical properties of nanomaterials and their design considerations for therapeutic and diagnostic applications. Int. Chem. This site needs JavaScript to work properly. et al. 5(13), 16271637 (2016), F. Li et al., Near-infrared light stimuli-responsive synergistic therapy nanoplatforms based on the coordination of tellurium-containing block polymer and cisplatin for cancer treatment. 1, a wide range of nanomaterials have been fabricated using organic, inorganic, lipid and protein compounds typically in the range of 1100nm and deliver various antitumor drugs by fine-tuning the chemical composition, size, and shape (morphology) that can control the functionality of the nanomaterials. Carbon nanotubes can assist as drug delivery systems for effective targeting to cancer cells. The design of highly efficient nanocarriers that meet the requirements for a drug delivery vehicle is an intricate process. These antitumor studies revealed that modified liposomes had lower systemic toxicity and prolonged the survival time of the treated mice by suppressing the tumor growth more strongly [234]. 3, 303312 (2005), Q. Liu et al., Differentiation of cancer cell type and phenotype using quantum dot-gold nanoparticle sensor arrays. In a related study, to treat the multidrug resistant cancer cells with elevated Bcl-2 levels, Xu et al. Better diagnostics. Moreover, due to the poor lymphatic function, the nanoparticles are not rapidly cleared and accumulate in the tumor interstitium [30]. have demonstrated that the internalization of magnetic nanoparticles inside HeLa cells is dependent on the nanoparticle surface charge and incubation time. Due to the morphological similarity with cellular membranes and ability to integratewith various substances, liposomes serve as an ideal drug-carrier systems. Rev. 47(4), 287296 (2017), A. Prasanna et al., Smart drug delivery systems for cancer treatment using nanomaterials. Lin, Effect of surface functionalization of MCM-41-type mesoporous silica nanoparticles on the endocytosis by human cancer cells. Mater. 13, 15051524 (2018), S. Malekmohammadi et al., Immobilization of gold nanoparticles on folate-conjugated dendritic mesoporous silica-coated reduced graphene oxide nanosheets: a new nanoplatform for curcumin pH-controlled and targeted delivery. Nat. J. Pharm. Adv. J. Pharm. 134, A. Umapathi et al., Impact of physicochemical properties and surface chemistry of nanomaterials on toxicity, in Nanotoxicology: toxicity evaluation, risk assessment and management, ed. Ferritin: A Promising Nanoreactor and Nanocarrier for Bionanotechnology. 65, 393404 (2018), H.K. Biotechnol. The graphene oxide based carrier was found to be effective in inhibiting and killing A549 cells, and displayed lesser toxicity against normal human bronchial epithelial cells [215]. But these problems may be from the chemotherapy drugs they. Additionally, a newer generation of liposomes are emerging, focusing on redox sensitive liposomes, magnetic liposomes, enzyme sensitive liposomes and multifunctional smart liposomes [242,243,244,245]. Chemical affinity for active targeting is based on different specific molecular interactions such as receptorligand-based interactions, charge-based interactions and facilitated motif-based interactions with substrate molecules [41, 42]. Small 11(44), 59195926 (2015), E. Niemel et al., Sugar-decorated mesoporous silica nanoparticles as delivery vehicles for the poorly soluble drug celastrol enables targeted induction of apoptosis in cancer cells. Zhang et al., designed pH sensitive TPGS-PAE nanoparticles, polymeric nanoparticles, wherein doxorubicin and curcumin were co-loaded by self-assembly. Similarly, the PEGylated liposomes have been used in delivering celastrol, irinotecan, resveratrol in the treatment of breast cancer and glioblastoma [236, 237]. Chou, I.M. 46, 921935 (2018), W. Xu et al., Macroporous silica nanoparticles for delivering Bcl2-function converting peptide to treat multidrug resistant-cancer cells. Negative Impact on Environment: With the advance of nanotechnology pollution has also been increased due to the nanoparticle produced during the making of various drugs, atomic bombs, etc. 2022 Mar 1;2(3):258-281. doi: 10.1021/acsbiomedchemau.2c00003. Am. have reported the in vitro anticancer effects of docetaxel conjugated Au doped apatite. have developed different shaped mesoporous silica nanoparticles (sphere, rod, and long rod) functionalized with fluorescein isothiocyanate (FITC) and rhodamine B isothiocyanate (RITC) for imaging and quantification of mesoporous silica nanoparticle uptake. Sci. 550(1), 170179 (2018), H. Gan et al., Enhanced delivery of sorafenib with anti-GPC3 antibody-conjugated TPGS-b-PCL/pluronic P123 polymeric nanoparticles for targeted therapy of hepatocellular carcinoma. Nagesh et al., PSMA targeted docetaxel-loaded superparamagnetic iron oxide nanoparticles for prostate cancer. Google Scholar, X. Gao et al., In vivo cancer targeting and imaging with semiconductor quantum dots. There are two categories of nanosystems, open-loop control systems and closed-loop control systems, grouped according to what activation factors stimulate drug release as schematically shown in Fig. Likewise, PEG capped Au nanoparticles coated with [Pt(1R,2R-diaminocyclohexane) (H2O)2]2NO3 were takenup, and localized in the lung epithelial and colon cancer cell lines showing more significant effects than the drug alone [128]. 131(4), 13601361 (2009), S.S. Agasti et al., Photoregulated release of caged anticancer drugs from gold nanoparticles. 9(2), 194201 (2013), P.M. Valencia et al., Effects of ligands with different water solubilities on self-assembly and properties of targeted nanoparticles. As illustrated in Fig. Normally, given the complexity of nanoparticles administration routes and undesirable interactions with non-specific molecules within the organisms, the difference in the nanoparticles affinity towards cancerous and normal cells would not be sufficient for high specificity and efficient delivery to the target site required for wide utility for biomedical applications. By using this website, you agree to our 48(61), 76407642 (2012), R. Vivek et al., pH-responsive drug delivery of chitosan nanoparticles as Tamoxifen carriers for effective anti-tumor activity in breast cancer cells. Invest. Uptake was less effective with the negatively charged particles, however, indicating the role of negative surface charge on the nanoparticles, which can reduce the undesirable clearance by liver cells [111]. J. Photochem. Biomaterials 32(33), 85488554 (2011), C.H.J. by A. Dhawan (CRC Press, Boca Raton, 2018), pp. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. It is evident that mesoporous silica nanomaterials are one of the promising nanocarriers for efficient delivery of cancer therapeutics due to their useful properties. J. Pharm. Nanotechnology for cancer diagnostics: promises and challenges. 24(40), 54765480 (2012), Z.J. The site is secure. Cancer is a disease with complex pathological process. Palazzolo S, Bayda S, Hadla M, Caligiuri I, Corona G, Toffoli G, Rizzolio F. Curr Med Chem. Theranostics 4(8), 834844 (2014), M. Li et al., Enhanced synergism of thermo-chemotherapy for liver cancer with magnetothermally responsive nanocarriers. 30(10), 25122522 (2013), J. Wu et al., Robust, responsive, and targeted PLGA anticancer nanomedicines by combination of reductively cleavable surfactant and covalent hyaluronic acid coating. Biomater. Federal government websites often end in .gov or .mil. The Clinical Translation of Organic Nanomaterials for Cancer Therapy: A Focus on Polymeric Nanoparticles, Micelles, Liposomes and Exosomes. Likewise, the in vivo distribution of nanoparticles indicated that highly charged nanoparticles were taken up by liver cells. eCollection 2022 Jun 15. 62(23), 6831 (2002), V. Angeles et al., The influence of surface functionalization on the enhanced internalization of magnetic nanoparticles in cancer cells. Biomater. Drug Deliv. Biochim. The noble metal nanostructures, particularly Au nanoparticles, are widely used for delivering drugs [140,141,142]. Mol. Drug Deliv. Targeting specificity and payload delivery capacity are two critical parameters required to optimize the efficiency and viability of a nanoparticle-based active targeted systems in in vivo settings. 12(8), 28112822 (2015), I.M. *P<0.05 vs TMZ-FaPEC@siRNA; #P<0.05 vs TMZ-PEC@siRNA; P<0.05 vs TMZ-FaPEC@SCR (d); visualization of tumor growth inhibition in male SpragueDawley rats implanted with C6 cells after treatment with different formulations (red arrow indicates the tumor) (e). Accessibility Mol. In a recent study, co-delivery of two chemotherapeutic agents (tamoxifen and imatinib mesylate) using a liposome carrier system was developed to treat breast cancer. Nanotechnol. Polym. Sokol et al., Development of novel PLGA nanoparticles with co-encapsulation of docetaxel and abiraterone acetate for a highly efficient delivery into tumor cells. The influence of surface coating on the toxicity and cellular uptake of Au nanorods were studied revealing the surface chemistry dependent cellular uptake of Au nanorods covered with poly(diallyldimethylammonium chloride) [PDDAC] [127]. Apart from iron oxide nanoparticles several other metal oxide nanoparticles have been constructed and used for imaging, and drug delivery applications [165, 189,190,191]. Daima et al., Complexation of plasmid DNA and poly(ethylene oxide)/poly(propylene oxide) polymers for safe gene delivery. Specifically, cationic magnetic nanoparticles are retained by the cells for extended period, inducing no cytotoxicity [116]. Specificity is defined as how effective the interaction is between the ligand-conjugated nanoparticles with their target molecules weighted against off-target effects incurred before reaching the target molecules. Radiotherapy and chemotherapy are known for significant adverse effects [2], with most methods targeting non-specifically any rapidly dividing cells irrespective of whether they are tumorous or not. These attractive properties along with low toxicity have enabled the nanomedicine research community to use organic nanomaterials as drug delivery vehicles to target specific tissues and controlled release of the drug molecules. Nanotechnology has the potential to facilitate the transport of drugs across the blood-brain barrier and to enhance their pharmacokinetic profile. Biogenic Ag nanoparticles can be employed against prostate and colon cancer. Mater. Res. All the authors have made substantial intellectual contribution in the preparation of the manuscript. Eur. In fact, significant strides have been made towards the application of engineered nanomaterials for the treatment of cancer with high specificity, sensitivity and efficacy.
Eviction Friendly Apartments In Phoenix Arizona,
Capillus Return Policy,
Will Texas Retired Teachers Get A Raise In 2022,
Somers In Alaska Religion,
Sacar Present Perfect,
Articles D